It might happen one morning when you wake up home alone. This could be normal, depending on your situation, but this morning will be different. While your environment will all seem exactly the same, you will notice that everything is quieter than usual.
If you go outside, you will notice a distinct lack of anything like birds, insects… or people. As far as you travel, you will not encounter another sentient human being. The entire world will be intact, it is just empty... except for you.
There are currently over 100,000 missing persons cases in the United States. Some are just normal cases of murder, or kidnappings. However, in others, the disappearance cannot be explained, and no remains of the person are ever located.